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转金属硫蛋白基因平菇对初成年、衰老和铅中毒小鼠学习记忆能力的影响

Effects on Learning and Memorizing Abilities of Varied Model Mice Fed with Transgenic Metallothinoein Mushroom

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【作者】 李汉臣生吉萍徐培培陈海荣茹炳根申琳

【Author】 LI Han-chen1,SHENG Ji-ping2,*,XU Pei-pei2,CHEN Hai-rong2,RU Bing-gen3,SHEN Lin2(1.Department of Food Engineering,Hebei Normal University of Science and Technology,Qinhuangdao 066600,China;2.College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China;3.College of Life Science,Peking University,Beijing 100871,China)

【机构】 河北科技师范学院食品工程系中国农业大学食品科学与营养工程学院北京大学生命学院中国农业大学食品科学与营养工程学院 河北秦皇岛066000北京100083北京100871

【摘要】 本文研究了转金属硫蛋白基因平菇对不同模型小鼠学习记忆能力的影响。结果表明:在小鼠饲料中掺入1%转金属硫蛋白基因平菇干粉(相当于50~60kg体重的人每日摄食鲜菇1kg)可明显提高初成年小鼠和铅中毒小鼠的学习能力;增加剂量对成绩提高无进一步的作用。3.16%的掺入量对提高初成年小鼠的记忆能力有显著作用。但1%和3.16%两个剂量对D-半乳糖致衰老小鼠的学习记忆能力均未见有促进作用。

【Abstract】 Effects on learning and memorizing abilities of varied model mice fed with transgenic metallothinoein(MT)mushroom were studied in this paper.The results showed that the dried transgenic MT mushroom could significantly improve learning ability of early adulthood mice and lead poisoning mice when there was 1% MT mushroom in mixed feed(corresponding to doses of 1kg/d to human whose body weight is 50~60kg).No further improvement was found when MT mushroom dosage increased.The dosage of 3.16% MT mushroom could significantly improve the memorizing ability of early adulthood mice,but there was no effect on improvement of learning and memorizing ability to senile mice caused by injecting D-galactose under skin with both dosage of 1% and 3.16% MT mushroom.

【基金】 国家自然科学基金项目(30200191)
  • 【分类号】R114
  • 【被引频次】2
  • 【下载频次】127
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