【摘要】 本文研究了菹草类胡萝卜素(CEPC)的抗癌作用及其对免疫功能的影响。以动物移植性肿瘤小鼠肝癌H22为模型,以环磷酰胺为阳性对照,以色拉油为阴性对照,观察5、10、20mg/kg·d的CEPC的体内抗肿瘤作用及其对荷瘤小鼠肝脏中MDA、SOD的影响,通过CEPC对二硝基氟苯(DNFB)诱导的迟发型变态反应(DTH),对淋巴细胞增殖反应的作用和NK细胞活性的测定来观察其对免疫系统的影响。结果表明低中高浓度的CEPC与阴性对照组相比对肝癌H22瘤细胞均有较强的杀伤力,对荷瘤小鼠肝脏中MDA有降低作用,对SOD有增强作用,且CEPC对小鼠免疫系统具有较强的激活作用。提示CEPC对移植性H22肿瘤小鼠具有抗肿瘤作用,并对免疫功能有调节作用。更多还原

【Abstract】 The antitumor activity and immune function of carotenoids from Potamogeton crispus L. (CEPC) were studied in thisarticle. Cyclophosphamide was the positive control and salad oil the negative control. H22-bearing mice were used as animalmodels. The changes of H22 tumor weight in vivo, the changes of MDA and SOD of liver in H22-bearing mice and the effect onimmune system such as DTH induced by DNFB, proliferation of lymphocytes and NK activity were investigated when differentdosage CEPC (5, 10, 20mg/kg·d) were used. It was shown that CEPC markedly inhibited tumor growth in the H22-bearing mice.It could also decrease MDA and increase SOD of liver in the H22-bearing mice. CEPC enhanced the immune function. So CEPChas both the antitumor effect and the immunity effect modulation.更多还原