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香菇多糖L-2对荷瘤小鼠TNF-α和IL-2的影响(英文)

Effect of Polysaccharide L-2 from Lentinus edodes on TNF-α and IL-2

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【作者】 阮征付晓芳周泉城胡筱波吴谋成

【Author】 RUAN Zheng1,2,FU Xiao-fang1,ZHOU Quan-cheng3,HU Xiao-bo1,WU Mou-cheng1,* (1.College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China;2.Department of Food Science and Engineering, College of Life Sciences, Nanchang University, Nanchang 330047, China;3.School of Agriculture and Light Industry Engineering, Shandong University of Technology, Zibo 255049, China)

【机构】 华中农业大学食品科学技术学院南昌大学生命科学学院食品科学与工程系 江西南昌330047山东理工大学轻工与农业工程学院湖北武汉430070山东淄博255049

【摘要】 我们提取纯化得到一种重均分子量为2.03×105、单糖为葡萄糖的香菇多糖级分(L-2)后,评价了香菇多糖L-2对荷S-180小鼠细胞免疫的影响。连续10d通过腹腔注射给予小鼠不同剂量的香菇多糖L-2(10mg/kg体重),测定了正常小鼠与荷S-180小鼠的血清中肿瘤坏死因子(TNF-α)和白介素2(IL-2)的含量,以及香菇多糖L-2对TNF-α和IL-2的mRNA表达的影响。与对照组小鼠相比,血清中TNF-α含量有显著增加,而血清中IL-2含量没有变化,与此同时,香菇多糖L-2可以上调TNF-α的mRNA的表达。结果揭示多糖L-2有增加TNF-α含量的作用,多糖增强免疫力与TNF-α含量增加以及在转录水平上调TNF-αmRNA的表达有关。

【Abstract】 The effects of the polysaccharide (L-2) extracted from Lentinus edodes on the immune response of Sarcoma 180- bearing mice were evaluated. Mice were treated with two doses of polysaccharide L-2 (1, 10mg/kg body weight) for 10 days. The concentration of tumor necrosis factor-alpha (TNF-α), interferon-2 (IL-2) in mice serum and TNF-α mRNA expression were determined. The concentration of TNF-α in serum increased significantly in two doses groups compared to the model control group, but IL-2 not. The level of TNF-α mRNA transcription increased significantly in two doses groups to the model control group. Results of these studies demonstrated the polysaccharide L-2 significantly promoted TNF-α production, immunity potentiating and anti-tumor effects of the polysaccharide L-2 were associated with its potentiation of TNF-α mRNA expression att het ranscriptionall evel.

【基金】 湖北省“十五”科技重点攻关项目(2001AA204A03)
  • 【分类号】R151
  • 【被引频次】22
  • 【下载频次】420
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