【摘要】 目的探讨新生儿缺氧缺血性脑病(HIE)严重程度与心肌损害的关系,为心肌损害的早期干预治疗提供依据。方法93例HIE新生儿于入院后24 h内采集血标本查心肌酶谱、肌钙蛋白I,做心电图、心脏超声检查。严格查体并记录。结果HIE越重心肌酶越高,其中磷酸激酶同工酶(CK-MB)、磷酸激酶(CK)、乳酸脱氢酶(LDH)在轻、中、重度HIE之间差异有极显著性(F=18.56~28.29,q=4.27~7.53,P<0.01)。新生儿HIE的分度与心肌酶中CK-MB、CK、LDH之间均存在正相关(rs=0.41~0.59,P<0.05)。不同程度新生儿HIE之间心电图异常、心脏超声异常、肌钙蛋白I阳性的差异有极显著性(χ2=8.15~10.09,P<0.01)。结论治疗新生儿HIE同时应加强新生儿缺氧缺血性心肌损害的检测与早期干预治疗。更多还原

【Abstract】 ObjectiveTo study the relationship between neonatal hypoxic ischemic encephalopathy(HIE) and myocardial damage,and to find evidence for early intervention of the disease.MethodsThis study consisted of 93 neonates with HIE who were detected for myocardial enzymes,troponin I,ECG and echocardiography within 24 hours after admission.Results(The higher) myocardial enzyme,the more serious pathogenetic condition was.CK-MB,CK and LDH showed significant differences between mild,moderate,and severe HIE(F=18.56-28.29,q=4.27-7.53,P<0.01).There was a positive correlation between the grade of HIE and CK-MB,CK,as well as LDH(r_s=0.41-0.59,P<0.05).The differences of troponin I,abnormal ECG and abnormal cardiac ultrasonogram were significant among different-degree HIE(χ~2=8.15-10.09,P<0.01).Conclusion(The treatment) of HIE should be accompanied by detecting myocardial damage and carrying out early intervention.更多还原