【摘要】 目的通过分析高血压矿工血浆内皮素(ET)水平,探讨ET在矿工高血压发病中的作用。方法对地面与井下作业的煤矿工人进行问卷调查和血压、身高、体重的测量,用放射免疫测定法测定高血压(HP)与非高血压(NHP)矿工血浆ET水平。结果高血压矿工血浆ET总体水平高于非高血压矿工(P>0.05),而临床高血压患者血浆ET水平更高,并显著高于高血压矿工(P<0.01)。在地面作业的矿工中,HP组血浆ET水平明显高于NHP组(P<0.01),且主要是超体重的高血压矿工,矿工血浆ET水平与体重指数(BMI)呈正相关(P<0.01)。相反,在井下作业的矿工中,HP组血浆ET水平反而低于NHP组(P<0.01),并显著低于地面作业的HP组矿工(P<0.01),矿工血浆ET水平与BMI呈负相关。结论ET水平与矿工高血压的发病及严重程度有重要关系。超体重者血浆ET水平较高,而井下作业可能降低了高血压矿工血浆ET水平。更多还原

【Abstract】 Objective To study the effect of plasma endothelin(ET)on the pathogenesis of hypertension in miners by analyzing plasma ET level.Method The questionnaire investigation was made in coal miners both underground workers or ground workers,their blood pressure,body height and body weight were measured,additionally,the levels of plasma ET were also measured by radioimmunoassay in hypertensive(HP)and non-hypertensive(NHP)miners.Result The plasma ET level in hypertensive miners was higher than that of non-hypertensive miners(P>0.05),while they were all lower than that of clinical hypertensive patients(P<0.01).The plasma ET level in ground HP workers,especially the overweighted,was much higher than that of NHP group(P<0.01),the plasma ET level showed positive correlation with body mass index(BMI)(P<0.01).But in underground miners,the plasma ET level of HP group was lower than that of NHP group(P<0.01),which was also much lower than that of ground miners’ HP group(P<0.01),and the plasma ET level showed negative correlation with BMI in underground miners.Conclusion The morbidity and severity of hypertension have close relationship with plasma ET level,the overweighted miners have higher ET levels;the results also suggest that underground work probably may reduce ET level of the miners.更多还原