【摘要】 为探讨p16基因表达与外阴鳞状细胞癌(V SCC s)发生、发展的关系,应用免疫组化法检测53例外阴上皮非瘤样病变(NNED)、7例外阴上皮内瘤变(V IN)及21例角化型V SCC s中p16蛋白的表达。结果显示,在NNED、V IN和V SCC s中p16高表达率(阳性细胞数≥5%)分别为86.7%、42.8%和28.6%,呈下降趋势(P<0.05)。V SCC s和V IN组中p16高表达率显著低于NNED组,差异有显著性(P<0.05),而在V IN组与V SCC s组之间相比较差异无显著性(P>0.05)。提示p16低表达或缺失可能是角化型V SCC s发生中的重要分子事件。更多还原

【Abstract】 To study the relationship between the expression of p16 protein and the tumorigenesis and progression of vulvar squamous cell carcinomas(VSCCs).We investigated 53 cases of non-neoplastic epithelial disorders(NNED),7 cases of vulvarintraepithelial neoplasia(VIN) and 21 cases of keratinizing VSCCs with immunohistochemical staining to determine expression of p16 protein.We observed a significant decrease of high p16(≥5% positive nuclei) protein expression rate from NNED(87.6%),through VIN((42.8%),) to VSCCs(28.6%)(P<0.05).The high expression rate of p16 protein was significant different between in NNED and in VIN and VSCCs(P<0.05).The results indicate that p16 may play an important role in vulvar carcinogenesis.更多还原