【摘要】 目的:观察感染乙肝病毒的孕妇在孕期接受HB IG注射后,其新生儿感染乙肝病毒的情况,以评价HB IG阻断乙肝母婴传播的效果。方法:448例HB sA g(+)孕妇在知情同意的情况下,随机分为两组。一组为实验组(即HB IG组),该组孕妇分别在孕32、36和40周时肌注HB IG 200IU;另一组为对照组,孕期未注射HB IG。两组孕妇所生新生儿在分娩时均取外周血测HB sA g和HBV-DNA,同时两组新生儿生后均进行乙肝的主被动免疫。结果:实验组新生儿宫内感染率为5.3%,对照组宫内感染率为14.5%(χ2=10.675,P<0.01)。结论:HB sA g(+)孕妇孕期注射HB IG能有效减少乙肝病毒的母婴传播。更多还原

【Abstract】 Objective: To inject HBIG before delivery for the HBsAg(+) pregnant women,then observe their neonates about status of HBV infection.To evaluate the interruptive effect of HBIG.Methods: 448 HbsAg(+) pregnant women were randomly divided into HBIG group and control group.Each subject in the HBIG group received 200 IU HBIG intramuscularly injection at 32 weeks,36 weeks and 40 weeks of pregnant.The subjects in the control group did not receive any specific treatment.Blood tests were performed for all the lying-in women and their neonates.Blood specimens were tested for HBsAg,HBsAb,HBeAg,HbeAb,and HbcAg by enzyme immunoassay,and HBV-DNA by PCR.All newborn infants received passive and active immunity of HBV.Results: The rates of intrauterine transmission in the two groups(HBIG group and control group) were 5.3% and 14.5% respectively(χ~2= 10.675,P<0.001).Conclusions: HBV infection of mother-to-child may be interrupted by injecting multiple intramuscularly HBIG injections before delivery.更多还原