【摘要】 目的:观察龙葵总碱对S180小鼠及H22小鼠肿瘤细胞膜Na+,K+-ATPase及Ca++,Mg++- ATPase活性的影响。方法:荷瘤小鼠分为治疗组(高剂量、中剂量、低剂量)和对照组(生理盐水组、环磷酰胺组),分别测定各组肿瘤细胞膜的Na+,K+-ATPase及Ca++,Mg++-ATPase活性。结果:龙葵总碱对S180小鼠及H22小鼠肿瘤细胞膜Na+,K+-ATPase及Ca++,Mg++-ATPase活性均有明显的抑制作用,并且其抑制作用呈量效正相关。结论:龙葵总碱这一作用可能是其抗肿瘤作用机理之一。更多还原

【Abstract】 Objective:To observe the effect of total alkaloids (TA) from Solarium nigrum on the activities of Na+,K+-ATPase and Ca++,Mg++-ATPase in tumor cells’membrance of S180 and H22 mice. Methods: Mice were divided into treated group (high, medium and low dosage) and control group (normal saline and cyclophosphamide), and the activities of Na+,K+-ATPase and Ca++,Mg++-ATPase in tumor cells’membrance were examined measured respectively. Results:TA showed pronounced inhibition on the activities of Na+,K+-ATPase and Ca++,Mg++-ATPase at in tumor cells’membrance, and it showedand the inhibition showed dose-effect positive relationship. Conclusion: This effect may be one of the mechanisms of its antitumor effect.更多还原