【摘要】 目的评价帕珠沙星治疗急性细菌感染的临床疗效和安全性。方法采用随机、双盲、对照试验的方法,治疗组为甲磺酸帕珠沙星注射液,对照组为左氧氟沙星,每组各20例,纳入对象为呼吸道、泌尿道感染,甲磺酸帕珠沙星用量:轻度感染500 mg Qd静滴;中度感染500 mg B id静滴。左氧氟沙星用量:轻度感染200 mg Qd静滴;中度感染200 mg B id静滴。疗程均为7~14 d。结果甲磺酸帕珠沙星的临床治愈率70.0%(14/20),有效率90.0%(18/20),细菌清除率87.5%(14/16);对照组左氧氟沙星分别为65.0%(13/20),90.0%(18/20),86.7%(13/15)。帕珠沙星和左氧氟沙星不良反应发生率均为8.7%。以上结果经统计学处理,差异均无统计学意义(P均>0.05)。结论甲磺酸帕珠沙星是治疗轻中度呼吸道、泌尿道感染有效、安全的抗菌药物。更多还原

【Abstract】 Objective To evaluate efficacy and safety of pazufloxacin mesilate in treatment of acute bacterial infections.Method A randomized,double blind and controlled trial with 20 pairs of patients with respiratory and urinary tract bacterial infection were treated with pazufloxacin mesilate(treatment group)and levofloxacin(control group)respectively.The dosage of pazufloxacin mesilate in treating low grade infection and midrange infection was 500 mg once daily and twice daily intravenous drop infusion respectively for 7-14 days.And the dosage of levofloxacin in treating low grade infection and midrange infection was 200 mg once daily and twice daily intravenous drop infusion respectively for 7-14 days.Result The results showed that the cure rate of pazufloxacin mesilate was 70.0%(14/20),the effective rate was 90.0%(18/20)and the bacterial clearance rate was 87.5%(14/16),while in levofloxacin group they were 65.0%(13/20),90.0%(18/20)and 86.7%(13/15) respectively.The adverse reaction rates of both pazufloxacin mesilate and levofloxacin were 8.7%.There were no statistical significant differences(P>0.05)between pazufloxacin mesilate and levofloxacin in overall results.Conclusion The study demonstrated pazufloxacin mesilate was an antibiotic of efficacy and safety in treating respiratory and urinary tract bacterial infection.更多还原