【摘要】 观察血府逐瘀胶囊对早中期糖尿病肾病(DN)血瘀证的疗效,采用随机方法将60例早中期DN患者,分为血府逐瘀胶囊治疗组和科素亚对照组各30例,疗程为8周,观察治疗前后两组临床症状积分、24小时尿蛋白定量、肾功能、血脂、血纤维蛋白原(FIB)、D-二聚体(DD)、血液流变学等变化。结果治疗组总有效率为76.6%,明显优于对照组的56.7%(P<0.05);血瘀症状改善率治疗组为84.6%,对照组为58.1%(P<0.05,P<0.01);两组24小时尿蛋白定量,肾功能均有改善,组间比较,P>0.05;治疗组中CCH、TC、FIB、DD及血液流变指标均有明显降低(P<0.05),对照组上述指标降低不明显,组间比较,P>0.05。结论血府逐瘀胶囊能有效缓解早中期糖尿病患者的临床表现,明显改善血瘀症状及生化指标,减少尿蛋白,降低血黏度,以及改善血脂和血液流变学指标。更多还原

【Abstract】 To observe the clinical effects of "Xuefu Zhuyu Granule" in the treatment of early and middle diabetic nephropathy,60 subjects were randomized into two groups:treatment group in which 30 cases were treated with this Granule and control group in which another 30 cases were treated with Losartan,with a course of 8 weeks. The clinical symptom score,24-hour urinary protein,kidney function,blood lipid,FIB,DD and blood rheology were observed before and after treatment. Results:The total effective rate was 76.6% in treatment group and 56.7% in control group,P < 0.05;the improvement rate of blood stasis was 84.6% in treatment group and 58.1% in control group,P < 0.05;24-hour urinary protein and kidney function improved little; the CCH,TC,FIB DD and blood rheology improved obviously after treatment in treatment group. It is indicated that this Granule is effective to relieve clinical symptoms and improve laboratory indexes.更多还原