【摘要】 目的观察健脾清化方对脾虚湿热型慢性肾衰患者临床疗效及白介素-2(IL-2)、白介素-6(IL-6)、尿转化生长因子(TGF-β)的影响,探讨“脾虚湿热”对加重慢性肾衰进展的机理。方法将106例脾虚湿热型慢性肾衰患者随机分为治疗组和对照组各53例,对照组针对慢性肾衰加重因素等治疗,治疗组在对照组治疗的基础上加用健脾清化方治疗。疗程60天。结果治疗组能明显改善慢性肾衰患者的临床症状,降低血肌酐(Scr)、尿素氮(BUN)和IL-6、尿TGF-β,使IL-2有显著的增加。结论早中期慢性肾衰在常规治疗的基础上加用健脾清化方,能改善患者的肾功能,降低蛋白尿“。湿热”作为加重CRF的影响因素,与高度表达的细胞生长因子和代表炎症的白介素对肾组织的损害有关,而“脾虚”与IL-2下降相关。更多还原

【Abstract】 Objective To observe the clinical effects of "Jianpi Qinghua Decoction" in treating chronic renal failure and its effect on IL-2,IL-6 and Urine TGF-β and further to study its mechanism.Method One hundred and six subjects were randomized into two groups:control group in which 53 cases were treated by routine therapy and treatment group in which 53 cases were treated by routine medicine plus "Jianpi Qinghua Decoction",with a course of 60 days.Results In treatment group,the clinical symptoms improved,blood Scr,BUN and urine TGF-β and IL-2 increased.Conclusion This Decoction can improve renal function and reduce urine protein.更多还原