【摘要】 为探讨复方苦豆子(CK)对肾性高血压大鼠(RHR)左室肥厚(LVH)及血浆血管紧张素II(AngII)的影响,建立了二肾一夹型高血压大鼠模型(2KⅠC-RHR),选取造模成功的大鼠57只,随机分为5组:模型组(Mod组),CK高、中、低剂量组(H、M、L组)和卡托普利组(Cap组),另取10只作为假手术组(Sham组)。每日灌药1次,连续8周。根据体重随时调整给药量。观察药物对模型动物左室肥厚指数(LVHI)及AngⅡ影响。结果表明:1)CK长期给药能明显降低模型动物的LVHI,H、M组与Mod组相比均有显著性差异(P<0.01),L组也有下降趋势,但无统计学意义。2)CK能降低模型动物血浆AngⅡ水平,与Mod组相比,各给药组均有显著性差异(P<0.01),以H组下降最为明显。这表明CK对RHR的心脏重塑有一定的防治作用,其机制可能与抑制肾素-血管紧张素系统(RAS)活性有关。更多还原

【Abstract】 To investigate the effects of compound kudouzi(CK) on left ventricular hypertrophy(LVH) and AngII in plasm in renal hypertensive rats(RHR),and analyze the possible mechanism.Methods:2-kidney 1-clip(2KⅠC) renovascular hypertension was induced in male wister rats.57 RHR were randomly divided into 5 groups as follows: model group(n=11),high dose of CK group(H groop),middle dose of CK group(M group,n=12),low dose of CK group(L group)and captopril group(Cap group,n=10),in addition,sham-operated group(sham group) were fed with drinking water too.All rats were treated once a day for 8 weeks,and the volumes of the drug were adjusted any time according to the changes of their weight.The left ventricular hypertrophy index(LVHI) and the levels of angiotension II(AngII) were measured.Results: Compared with model group,the LVHI were significantly decreased in H and M groups.L group had the tendency of decline,but had no significance.The concentration of AngII in plasma of H group is much lower than in moddle group(P<0.01).Conlusion:Chronic use of CK can inhibit and reverse ventricular hypertropy,and the effect is relatively dose-dependent.Decreasing activity of RAS probably is one of the mechanisms.更多还原