【摘要】 目的:观察滋阴狼疮胶囊治疗系统性红斑狼疮(SLE)的临床疗效及对皮质醇、GRαmRNA的影响。方法:70例SLE患者随机分为两组:对照组30例,以糖皮质激素治疗;治疗组40例,以糖皮质激素和滋阴狼疮胶囊治疗。另选20例健康人作为正常组。应用化学发光法测定血清皮质醇,逆转录酶-聚合酶链反应法检测GRαmRNA,观察其与正常人差异及治疗前后的变化。结果:治疗组总有效率为90%,对照组为80%,治疗组明显高于对照组(P<0.05);两组患者血清皮质醇水平与正常人相当(P>0.05),而GRαmRNA表达明显低于正常人(P<0.05)。治疗后,对照组GRαmRNA下调水平高于治疗组(P<0.05)。结论:滋阴狼疮胶囊可增强糖皮质激素的临床疗效,其增效作用可能是通过调控GRmRNA水平实现的。更多还原

【Abstract】 Objective: To investigate the effect of "Ziying Langchuang Capsule" on the level of serum cortisol and GRα mRNA in treating systemic lupus erythematosus(SLE).Methods: Seventy patients with SLE were randomized into two groups: control group in which 30 cases were treated with glucocorticoid and treatment group in which 40 cases were treated with this Capsule and glucocorticoid;and another 20 healthy people were observed as normal group.Measurement of the levels of serum cortisol and glucocorticoid receptor-α mRNA(GRα mRNA) in different groups were performed before and after treatment.Results: The total effective rate was 90% in treatment group and 80% in control group;the SLE patients had the same serum cortisol leverl as the healthy people,and lower GR mRNA level.While the patients had higher GRα mRNA level than healthy people(P < 0.05).After treatment,GR mRNA level increased more obviously in treatment group than in control group(P < 0.05).Conclusion: This Capsule helps glucocorticoid in the treatment of SLE possibly by upregulating GRα mRNA.更多还原