【摘要】 蛋白质异常修饰导致错误折叠的机制目前尚不清楚.提出如下设想:细胞内的蛋白质分子可能发生多种异常修饰,引起蛋白质选择性错误折叠和聚积而导致神经退行性疾病.更多还原

【Abstract】 Although the relationship between abnormal chemical modification and protein misfolding has been widely studied, most work is focused on the effect of a single factor on the structure and function of a protein. Here, it is proposed that a combination of multiple factors may modify selected proteins in vivo, and lead to their misfolding and aggregation in certain cell types.更多还原