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“反向免疫学”与免疫功能基因的发现

"Reverse Immunology" and The Discovery of Immune-related Functional Genes

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【作者】 冯晨张建田志刚

【Author】 FENG Chen, ZHANG Jian, TIAN Zhi-Gang*(Shandong University, Institute of Immunopharmacology and Immunotherapy, Jinan 250012, China)

【机构】 山东大学药学院免疫药理与免疫治疗学研究所山东大学药学院免疫药理与免疫治疗学研究所 济南250012济南250012

【摘要】 人类基因组测序的结束为生命科学领域展开了全新的一章.尽管已经得到了人类基因组的序列,但是隐藏在DNA序列中的功能基因,它们之间的相互作用以及对整个机体的意义大部分有待发掘.近些年来形成的“反向生物学”为免疫功能基因的发现、功能的研究及其应用价值提供了一套全新的技术与思路.

【Abstract】 The completion of sequencing human genome creates a new era of biological science and technology. Although the sequence of the human genome has been known, it is still hard to rapidly explore the whole functional genes, especially, their interaction with each other and the meaning to the body. However, the "reverse biology" which comes into being in the recent years provides us a series of novel ideas and technologies for discovering new functional gene, among which the immune-related genes have attracted more attentions, clarifying how functional gene works and their potential value in application.

  • 【文献出处】 生物化学与生物物理进展 ,Progress in Biochemistry and Biophysics , 编辑部邮箱 ,2006年06期
  • 【分类号】R392
  • 【被引频次】2
  • 【下载频次】205
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