【摘要】 目的:探讨异位宁治疗子宫内膜异位症的作用机制。方法:采用大鼠自体子宫内膜移植建立实验性子宫内膜异位症模型,分别观察异位宁和达那唑对模型大鼠外周血清白介素2(IL2)、白介素10(IL10)、雌二醇(E2)、孕酮(P)含量及血管内皮细胞生长因子(VEGF)在大鼠异位内膜组织中表达的影响。结果:异位宁对上述指标均有不同的下调或抑制作用,与模型组比较有显著性差异(P<0.05),异位宁高剂量组与达那唑相比无显著性差异(P>0.05)。结论:异位宁具有调节免疫、内分泌及血管内皮细胞生长因子作用,能够有效抑制异位子宫内膜的种植。更多还原

【Abstract】 Objective: To study the effect and mechanism of Yiweining on treatment of endometriosis. Methods: To set up endometriosis model by rat self-endometria transplantation, IL-2、IL-10、E₂、P of serum and VEGF of endometriosis tissue were detected. Results: The five parameters were depressed by Yiweining. There was significant difference of each target between Yiweining group and model group（P<0.05）. There was no significant difference of each target between the high dose of Yiweining group and Danazol group （P>0.05）. Conclusion: Yiweining can inhibit the growth of endometrial transplants, which is relates with the VEGF of dometriotic tissue and serum cytokines and hormone.更多还原