【摘要】 目的:探讨尼多考米钠治疗变应性鼻炎的效果。方法:采用甲苯2,4二异氰酸酯(TDI)致敏兔制作变应性鼻炎动物模型,观察尼多考米钠治疗前后实验动物症状和体征的变化,同时应用组织病理学方法观察鼻黏膜的改变。结果:应用尼多考米钠处理后,实验动物症状和体征明显改善,HE染色示治疗组鼻黏膜未见水肿及炎性细胞浸润,对照组可见鼻黏膜水肿,血管扩张及炎细胞浸润。结论:尼多考米钠能缓解鼻充血、流涕及喷嚏等症状,达到治疗变应性鼻炎的目的。更多还原

【Abstract】 Objective: To explore the effect of nedocromil sodium on allergic rhinitis.Methods: Toluene 2,4 diisocyanate(TDI) was used to sensitize white rabbits as allergic rhinitis models,and nedocromil sodium was used to treat the disease.The changes in nasal mucosa were studied by pathological methods.Results: Symptoms of allergic rhinitis were remarkably relieved after nedocromil sodium treatment.Hematoxylin and eosin staining demonstrated that no edema was found in the nasal mucosa,and small vessels were normal after nedocromil sodium application;whereas edema,vasodilation and inflammatory cell infiltration were discovered in the control group.Conclusion: Nedocromil sodium has salutary effect on alleviating the symptom of nasal congestion, rhinorrhea and sneezing,and on reducing the sensory neuron sensitivity of the mucosa.更多还原