【摘要】 目的:评价曲安奈德和透明质酸钠对山羊颞下颌关节骨关节病的治疗效果。方法:对9只山羊的双侧颞下颌关节上腔一次性注射胶原酶而诱导骨关节病变后,分三组,每组3只。对照组中3只山羊关节上腔注射1 ml生理盐水,两治疗组关节上腔分别注射1 ml曲安奈德和1 ml透明质酸钠,处死后对关节进行光镜和扫描电镜观察。结果:在光镜下观察,与对照组的典型骨关节病病理特征比较,透明质酸钠治疗组表现出较轻的骨关节病病理变化,而曲安奈德治疗组中则表现出严重的骨关节病变化。扫描电镜与光镜下观察结果一致。结论:通过3个月的观察和研究结果表明,用曲安奈德关节上腔封闭能加重骨关节病病理变化,而用透明质酸钠关节上腔封闭能抑制颞下颌关节骨关节病的发展进程。更多还原

【Abstract】 Objective:To investigate the efficacy of triamcinolone acetonide and sodium hyaluronate for treatment of temporomandibular joint(TMJ) osteoarthrosis of goats.Methods: The upper compartments of both joints of 9 goats were injected with collagenase to induce osteoarthrosis.The 9 goats were devided into 3 groups,3 goats per group.The upper compartments of both TMJs in three goats in control group were injected with 1ml physiological saline and in the two treatment groups were injected with 1ml triamcinolone acetonide and sodium hyaluronate,respectively.The TMJs of goats were examined under light microscopy and scanning electron microscopy after being sacrificed,and were scored in a subjective manner following the standard criteria which was a modification of the method of Mankin,et al and Yoshimi,et al.Results: Under light microscopy,the treatment group with sodium hyaluronat showed a light osteoarthrotic changes and the treatment group with triamcinolone acetonide showed more severe osteoarthrotic changes when comparing with the control group.Result under scanning electron microscopy accorded with the result under microscopy.Conclusion: On the basis of 3-month following-up,intra-articular injection of triamcinolone acetonide will aggravate the osteoarthrotic changes while intra-articular injection of sodium hyaluronate seems to curb the development of temporomandibular joint osteoarthrosis.更多还原