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Monastrol对人肺腺癌细胞系A549有丝分裂影响的研究
Effect of monastrol on mitosis in human pulmonary adenocarcinoma cell line A549
【摘要】 目的:探讨Monastrol对人肺腺癌细胞系A549有丝分裂的影响。方法:Monastrol处理A549细胞,免疫荧光染色观察细胞形态并计数,流式细胞术分析细胞周期变化。结果:Monastrol阻滞人肺腺癌细胞系A549有丝分裂于前中期,且分裂期细胞表现为单极纺锤体。结论:Monastrol影响肺癌细胞有丝分裂,抑制肺癌细胞生长,可用于肺癌药物治疗。
【Abstract】 Objective:To explore the influence of monastrol on mitosis in human pulmonary adenocarcinoma cell line A549.Method: Immunofluorescence stainning and fluorescence-activated cell sorting techniques were used to detect the the count of cells and the cell cycle.Result: A549 cell was blocked in prometaphase by monastrol and the mitosis cells were monopolar spindle-like.Conclusion: Monastrol can influence mitosis of lung cancer cells,and therefore inhibits the growth of lung cancer cells.
【基金】 国家自然科学基金资助课题(30371564);山东省自然科学基金资助课题(Y2001C21)
- 【文献出处】 山东大学学报(医学版) ,Journal of Shandong University(Health Sciences) , 编辑部邮箱 ,2006年07期
- 【分类号】R734.2
- 【被引频次】2
- 【下载频次】114