【摘要】 目的比较利培酮与氟哌啶醇治疗双相躁狂的疗效和安全性。方法82例双相躁狂患者随机分配至利培酮组和氟哌啶醇组,在治疗前、治疗第1周末、第2周末、第4周末分别进行Bech-Rafaelsen躁狂量表(BRMS)、不良反应症状量表(TESS)、锥体外系副反应量表(RSESE)评定。结果利培酮组患者有效率为82．5%,氟哌啶醇组为80．9%；与药物有关的不良事件发生率：利培酮组为57．5%,氟哌啶醇组为66．7%；两组差异无统计学意义(P＞0．05)。利培酮组锥体外系反应的发生率(40%)明显低于氟哌啶醇组(57%),差异有统计学意义(P=0．039)。结论利培酮单药治疗双相躁狂的疗效与氟哌啶醇相当,且锥体外系不良反应少于氟哌啶醇。更多还原

【Abstract】 Objective To evaluate the efficacy and safety of risperidone and haloperidol in treating manic epi- sodes of bipolar disorder.Methods A total of 82 patients were randomly divided into two groups treated with risperidone(n=40)or haloperidol(n=42).The patients were evaluated with the Bech-Rafaelsen Mania Rating Scale,TESS,RSESE before treatment and on 1st,2nd and 4th weekend after treatment.Results The clinical re- sponse rates were 82.5% in risperidone group and 80.9% in haloperidol group.There was significantly lower rate of extrapyramidal symptoms in risperidone group(40%)than that in haloperidol group(57%).Conclusion Risperidone has similar therapeutic effect to haloperidol in the treatment of manic episodes,but risperidone has better tolerability.更多还原