【摘要】 探讨食管癌组织中CyclinB1、Cdk1、PCNA和Ki-67的表达及其临床病理学意义.采用免疫组织化学SABC法,检测CyclinB1、Cdk1、PCNA和Ki-67在食管癌组织细胞中的表达.CyclinB1和Cdk1染色定位于细胞浆和细胞核.PCNA和Ki-67染色定位于细胞核.在所研究的食管癌病例中,CyclinB1阳性表达的病例占92.9%,Cdk1阳性表达的病例占78.6%,100%的病例均呈PCNA和Ki-67阳性表达.CyclinB1、Cdk1、PCNA和Ki-67在食管癌组织中均出现高频率的表达.CyclinB1、Cdk1、PCNA和Ki-67的阳性表达率及表达强度同食管癌分化程度有密切的关系.更多还原

【Abstract】 The clinicopathological significance of CyclinB1,Cdk1,PCNA and Ki-67 in esophageal carcinoma is the focus of investigation.The expression of CyclinB1,Cdk1,PCNA and Ki-67 was examined by SABC immunohistochemiscal technique in the tissues of esophageal carcinoma.Immunoreaction of CyclinB1 and Cdk1 was localized in the cytoplasm and nucleus of cells.Expression of PCNA and Ki-67 was localized in nucleus.The positive rate of CyclinB1,Cdk1,PCNA and Ki-67 was 92.9%,(78.6%,)100% and 100% respectively.CyclinB1,Cdk1,PCNA and Ki-67 play a role during the development of esophageal carcinoma,and have close relationship with malignant degree of esophageal carcinoma.更多还原