【摘要】 目的探讨可逆型梗阻性黄疸兔血液流变性改变。方法用止血钳钳夹胆总管造成实验兔可逆型梗阻性黄疸。以贝克曼全自动生化分析仪测定血清胆红素(TBIL和DBIL)、胆汁酸(BA);用STEELLEX R20血液粘度仪测定血液流变性。结果对照组(假手术后7d)TBIL、DBIL、BA为(5.90±1.49)(、1.60±0.58)和(21.06±5.86)μmol/L;梗阻黄疸组(7d)分别为(31.13±6.98)(、16.70±5.20)和(61.52±20.54)μmol/L,显著升高(P<0.01);梗阻3~30d,TBIL、DBIL、BA均逐渐增加。对照组全血粘度(低切、中切L、中切H、高切)值为(3.63±0.12)、(4.65±0.16)、(7.58±0.44)、(13.73±1.10),血浆粘度值(2.82±0.51),与正常组无明显差异(P>0.05);梗阻黄疸组(7d)全血粘度值为(4.17±0.33)、(5.38±0.60)、(9.07±1.09)(、16.88±2.90),显著高于对照组(P<0.05或0.01),血浆粘度值为(1.62±0.10),显著低于对照组。梗阻3~14d,实验组全血粘度逐渐增大,血浆粘度逐渐减小;梗阻30d组全血粘度不再增大,血浆粘度不再减小。结论梗阻性黄疸可显著影响血液流变性。更多还原

【Abstract】 Objective The hemorheological changes in rabbits with reversible obstructive jaundice is experimentsally studied.Methods The general bilie ducts of experimental rabbits were gripped with a 15cm hemostatic-pincers to induce reversible obstructive jaundice.Their Serum bilirubin(TBIL and D)BIL)and bile acid(BA)were assayed later with a Backman biochemical auto-analyzer;and their hemorheological properties were determined with STEELLEX R20 hemo-viscosimeter.Results The TBIL,DBIL and BA of the control group(7 days after sham operation)were(5.90±1.49),(1.60±0.58)and(21.06±5.86)μmol/L.These indexes in the reversible obstructive jaundice group(7d)were(31.13±6.98),(16.70±5.20) and(61.52±20.65)μmol/L,significantly increased over the control(P<0.01).In 3 to 30d after grip,TBIL,DBIL and BA in reversible obstructive jaundice groups were continuously increasing.It was demonstrated that the whole blood viscosities(high-,middle-high-,middlelow-,and low-shearing rate)were(3.63±0.12),(4.65±0.16),(7.58±0.44) and(13.73±1.10),and the plasma viscosity was(2.82±0.51) in control group being of no evident difference to those in normal group(P>0.05).The whole blood viscosities in reversible obstructive jaundice group(7d)were(4.17±0.33)、(5.38±0.60)、(9.07±1.09)、(16.88±2.90),significantly higher than those in control group(P<0.05 or 0.01);and the plasma viscosity in this group was(1.62±0.10),significantly lower than that in control group.The whole blood viscosities were increasing and the group was(1.62±0.10),significantly lower than that in control group.The whole blood viscosities were increasing and the plasma viscosities decreasing continuously in 3 to 14d groups with reversible obstructive jaundice;and in 30d group the both were recovering.Conclusion The reversible obstructive jaundice may be of significant effects on the rheolgical properties of peripheral blood.更多还原