【摘要】 目的:观察注射用黄芪冻干粉对动物心血管系统、中枢神经系统、呼吸系统的影响。方法:以不同剂量黄芪冻干粉给予小鼠和麻醉犬静脉注射,观察药物对动物各系统的影响。结果:注射用黄芪冻干粉各剂量(生药70.0g/kg、35.0g/kg、7.0g/kg)组对麻醉犬血压、心率有显著降低和减慢作用;对心电图PR间期、QT间期、ST间期有显著延长影响(P<0.01);但对QRS、T波、P波、心动节律无明显影响;对犬呼吸系统无明显影响(P>0.05);对小鼠自主活动无明显影响,并不影响小鼠戊巴妥钠阈下催眠剂量(P>0.05)。结论:注射用黄芪冻干粉明显降低犬血压、减慢心率,显著延长心电图PR间期、QT间期、ST间期,但对QRS、T波、P波、心率节律和呼吸系统(呼吸频率、深度、节律)无明显影响;对小鼠中枢神经系统无抑制作用。更多还原

【Abstract】 Objective:To investgated whether Lyophillized Powder of Astragalus(LPA) has any influences on cardiovascular system,the nervous system,and respiratory system of animals.Methods : Mice and anesthetized dogs were intravenously injected with different doses of LPA and negative control was set up.Various item of indexs were investagted. Results : With the dosage of 70.0g/kg,35.0g/kg,7.0g/kg respectively by intravenous injection,LPA decreased blood pressure and heart rate;and obviously prolonged PR intermediate stage,QT intermediate stage,ST intermediate stage of ECG;but there were no change on the QRS,T wave,P wave,cardiac rhythm and respiration.LPA with the dosage had no effect on the subthreshold hypnotic dosage of phenobarbital sodium(P>0.05);with the dosage,LPA had no obvious effect on the nervous system of mice(P>0.05).Conclusion : these results indicate that LPA obviously prolong prolonged PR intermediate stage,QT intermediate stage,ST intermediate stage of ECG;there were no change on the QRS,T wave,P wave,cardiac rhythm and respiration(breathing frequency,depth,rhythm) of anesthetized dogs;LPA had no obvious effect on the central nervous system of rats;but it decreased blood pressure and heart rate.更多还原