【摘要】 目的观察新的肿瘤放疗增敏药9401号对离体Hela细胞的细胞毒性和体外放射增敏作用。方法采用细胞克隆形成法研究9401号的细胞毒性和放射增敏作用。结果9401号对Hela细胞有较强的细胞毒性,随着药物浓度增加而增加,半数抑制剂量(ID50)为4.65 mg/ml。用3 mg/ml的9401号药作用于Hela细胞3,6,12和24 h后,各组均可见放射增敏效应,相应的放射增敏比SERDO分别为1.33,1.5,1.63和1.67;SERDq分别为1.38,1.89,2.47和3.33;SERSF2分别为1.32,1.82,2.41和3.02。结论9401号对Hela细胞的细胞毒性呈剂量依赖性关系。放射增敏作用明显,随药物作用时间延长而增强。更多还原

【Abstract】 Objective To investigate the cytotoxicity and radiosensitization of 9401 on Hela cells. Methods The cytotoxicity and radiosensitization of 9401 were investigated by using clongenic assay on Hela cells in vitro.Results The cytotoxicity of 9401 was in a dose-dependent manner.The 50% inhibition concentration of 9401 was 4.65?mg/ml.With 3?mg/ml 9401 exposed to Hela cells for 3,6,12 and 24 hours,the corresponding SERDO was 1.33,1.5,1.63 and 1.67;SER_Dq was 1.38,1.89,2.47 and 3.33;SERSF2 was 1.32,1.82,2.41 and 3.02.Conclusion The cytotoxicity of 9401 was in a dose-dependent manner.9401 has a radiosensititizing effect,and the radiosensitization is dependent on time.更多还原