【摘要】 目的观察E838的体内抗肿瘤活性,探讨其体内抑瘤作用的机制。方法取E838三个剂量对小鼠S180癌细胞实体瘤模型,进行体内抑瘤及合用137Csγ射线放射增效实验,测定肿瘤生长曲线、骨髓有核细胞(BMNC)数及脾脏、胸腺重量的变化,计算肿瘤生长抑制率。结果E838低、中、高三个剂量对小鼠S180的抑瘤率分别为49.52%、54.81%、53.85%,合用1Gy137Csγ射线抑瘤率分别为52.12%、59.62%、59.62%,其成瘤时间晚于对照组,肿瘤生长速度明显减慢,BMNC数均高于对照组,有统计学意义。结论E838对小鼠S180肿瘤的生长有明显的抑制作用,同时具有放射增敏效应。更多还原

【Abstract】 Objective To observe E₈₃₈’s activity of reatraining turmor growth in mouse and discuss the relative mechanism.Methods [WTBZ] We used three different doses of E₈₃₈ to restrain turmor growth in S180 mouse in one team and the other used ¹³⁷Csγtogether. Results In one team,the percent of the E₈₃₈ （dose: low to high）restraining turmor growth is respectively 49.52%、54.81%、53.85%,in the other is respectively 52.12%、59.62%、59.62%.Not only the turmor growth of the latter team is slow but the amount of BMNC is high Conclusion E₈₃₈ can obviously restrain the turmor growth in s180 mouse and has the radiation augment effect.更多还原