【摘要】 目的观察第三代β-受体阻滞剂卡维地洛治疗不稳定型心绞痛(UAP)的临床疗效。方法选择UAP患者68例,随机分为卡维地洛组(n=34)和对照组(n=34),观察用药8周后的临床治疗有效率、心电图变化、心率、血压及不良反应等。结果卡维地洛组临床显效率及总有效率明显高于对照组(P<0.05);卡维地洛治疗后收缩压、舒张压及心率均明显降低(P<0.05),血脂、血糖无明显改变;卡维地洛组肝、肾功能未发现异常,未见不良反应。结论卡维地洛治疗不稳定型心绞痛患者是有效而且安全的。更多还原

【Abstract】 Objective To evaluate the efficacy of Carvedilol, the 3rd generation β-receptor blocker, on patients with unstable angina pectoris (UAP). Methods 68 patients with UAP were randomly divided into two groups.34 patients in the study group were treated with Carvedilol,34 patients in the control group received placebos. The effective rate was determined 8 weeks after the treatment. Results The total effective rate of the study group was significantly higher than the control group (94.1% vs 79.4%, P<0.05). Carvedilol was found to lower the blood pressure and heart rate. Carvedilol also improved ST-T on ECG. Adverse effect of Carvedilol on the blood lipid and blood sugar level was not observed. Conclusion Carvedilol is effective in treating patients with UAP.更多还原