【摘要】 目的了解检出金黄色葡萄球菌的耐药状况,为临床抗生素的应用提供依据。方法按照卫生部颁布的全国医学检验操作规程及试剂说明书进行药敏试验,结果按照NCCLs的标准进行判断。结果金黄色葡萄球菌分离株中的耐甲氧西林金黄色葡萄球菌(MRSA)检出率为47.7%(82/172)。MRSA对多数常用抗生素的耐药率高达92%~100%,且与甲氧西林敏感金黄色葡萄球菌(MSSA)相比,其耐药率显著高。MRSA对万古霉素、利福平和氧哌青霉素/他唑巴坦相对敏感。未发现耐万古霉素金黄色葡萄球菌。结论MRSA检出黄色葡萄球菌中占较大比率,且表现为多重耐药;万古霉素、利福平和氧哌青霉素/他唑巴坦可做为MRSA感染的首选治疗药物。更多还原

【Abstract】 Objective To analyze the drug-resistant status of Staphylococci aureus in various clinical samples and provide basis for clinical use of antibiotics. Methods The detection of microorganisms was conducted according to "The Regulations of operation for clinical laboratories in the People,s Republic of China" formulated and promulgated by the Ministry of Health and the inset sheet of the reagents.The results of drug sensitivity tests were judged by NCCLs. Results The detection rate of methicillin-resistant Staphylococci aureus(MRSA) was 47.7%(82/172) among total isolates of Staphylococci aureus.The rate of most MRSA isolates resistant to commonly-used antibiotics was as high as 92%～100%,significantly higher than that of methicillin-sensitive Staphylococci aureus(MSSA).MRSA isolates were relatively sensitive to vancomycin,rifampin and Piperacillin/Tazobactam.No vancomycin-resistant Staphylococcus aureus isolate was detected. Conclusion MRSA is of multiple-resistance.Vancomycin,rifampin and piperacillin/tazobactam are the first choice of drugs for the treatment of the infection of MRSA.更多还原