【摘要】 目的观察双氢青蒿素哌喹片对云南省恶性疟的疗效和安全性。方法在云南边境抗药性恶性疟流行区选择恶性疟患者69例,用双氢青蒿素哌喹片2d 4次疗法治疗并追踪观察28d。结果治愈率为100%,平均退热时间(34.99±16.51)h;平均无性体原虫转阴时间(33.14±11.91)h;配子体转阴率为95.46%,临床及实验室检查均未见明显不良反应。结论双氢青蒿素哌喹片2d 4次疗法治疗云南恶性疟具有高效、速效、低毒、疗程短、服药依从性高、配子体转阴率高等优点。更多还原

【Abstract】 Objective To observe the effect and safety of Dihydroartemisinin Piperaquine Phosphate Tablets(DPPT) in treatment of falciparum malaria in Yunnan Province. Methods 69 falciparum malaria cases,who came from the endemic areas of drug resistant falciparum malaria on the border of Yunnan Province,were treated with 4 dosages of DPPT in 2 days and then followed-up for 28 days. Results The cure rate was 100%,no recrudescence was observed,the mean fever subsidence time was(34.99±16.51)h,the mean clearance time of asexual parasites in blood was(33.14±11.91)h,the clearance rate of gametocytes was 95.46%,no significant adverse effect encountered. Conclusion DPPT possesses advantages of high efficacy,quick acting,low toxicity,short course,high compliance and high rate of in clearance of gametocytes for treating falciparum malaria with 4 dosages in 2 days in Yunnan Province.更多还原