【摘要】 为了评价国产多西他赛(商品名为多帕菲)周剂量单药联合放疗对晚期非小细胞肺癌(non-small-celllungcancer,NSCLC)的近期疗效和毒副反应,将105例Ⅲ期NSCLC患者随机分为单纯放疗组(50例)与多帕菲加放疗组(55例)。多帕菲加放疗组于放疗前1周开始用药,采用每3周休1周方案,多帕菲35mg/m2溶于250mL生理盐水中,静脉滴入,d1、d8、d15,28d为1个周期,至少完成2个周期。常规放疗2Gy/次,1次/d,每周5d,肿瘤灶总剂量66Gy/7周。结果单纯放疗组与多帕菲联合放疗组有效率分别为58%(29/50)和80%(44/55),中位疾病进展时间(TTP)分别为7·8和12个月,1年生存率分别为40%(20/50)和66%(33/55)。两组比较差异有统计学意义,χ2值分别为5·9827、4·1909,P值分别为0·0144、0·0406。两组放射性食管炎和肺炎发生率分别为32·0%、36·4%;中性粒细胞降低分别为64·0%和70·9%,两组比较差异无统计学意义,χ2值分别为0·2213和0·5710,P值分别为0·6380和0·4499。初步研究结果提示,周剂量多帕菲加放疗同步治疗局部晚期NSCLC,近期疗效肯定,远期疗效和晚期并发症有待进一步观察。更多还原

【Abstract】 The objective of this study was to evaluate the short-term efficacy and acute side-effects of Docetaxel (Dopaphy) plus synchronous radiotherapy in the treatment of stage Ⅲ non-small-cell lung cancer (NSCLC). One hunderd and five patients with stage Ⅲ NSCLC were divided into two groups randomly. Fifty were treated with radiotherapy alone (Group A) and the other 55 patients were treated with Dopaphy in combination with radiotherapy (Group B).In Group B, Dopaphy was admiaistered (35 mg/m~2 in 250 mL saline solution, given intravenously on the day 1,8,15, repeated in every 28 days and at least two cycles) one week before radiotherapy. Regular radiotherapy was given 2 Gy/time, once per day and five days a week. The total dose in the tumor lesion was 66 Gy/(seven weeks). The efficient rates of Group A and B were 58%(29/50) and 80%(44/55) respectively, the time to progress (TTP) was 7.8 and 12 months respectively and the one-year survival rates were 40%(20/50) and 66%(33/55) respectively. The difference had a statistical significance, P<0.05. Main toxic side effects were acute radiation esophagitis, pneumonia (32.0% in Group A and 36.4% in Group B), and neutropenia (64.0% in Group A and 70.9% in Group B). The difference did not have statistical significance, P>0.05. In conclusions, concurrent radiotherapy and chemotherapy can be considered as an effective and feasible approach for treating NSCLC with good responds and little early serious complications. The long term survival and specific injury need further study.更多还原