【摘要】 目的:探讨血管内皮生长因子受体-3(vascular endothelial growth factor,VEGFR-3)在非小细胞肺癌(non-small-cell lung cancer,NSCLC)组织中表达及其与临床病理特征的关系。方法:应用免疫组织化学方法检测60例NSCLC和15例正常肺组织中VEGFR-3的表达。结果:VEGFR-3在NSCLC中的阳性表达率70%(42/60)高于正常肺组织13%(2/15),P=0·000;与患者的年龄、性别、分化程度以及组织类型之间比较差异无统计学意义,P>0·05。VEGFR-3的阳性率随着肺癌TNM分期增加而增高;在有淋巴结转移组显著高于无淋巴结转移组,P=0·003。结论:VEG-FR-3表达与NSCLC的TNM分期及淋巴结转移密切相关,可作为评估NSCLC转移潜力和判断预后的指标。更多还原

【Abstract】 OBJECTIVE:To explore the expression of VEGFR-3 in NSCLC and the relationship between VEGFR-3 and the clinical pathological characteristics. METHODS: The immunohistochemical method was used to detect the expression of VEGFR-3 in 60 NSCLC and 15 normal lung tissues. RESULTS: The positive expression rate in NSCLC70%(42/60) of VEGFR-3 was higher than that in the normal lung tissue group13%(2/15)P=0.000), and had no statistical difference with the age,sex,degree of differention and pathological type,P>0.05. The elevation of positive VEGFR-3 expression accompanied the increase of TNM stage. VEGFR-3 expression was statistically higher in the lymph node metastasis was group than that was in the no lymph node metastasis group,P<0.05. CONCLUSIONS: The expression of VEGFR-3 in tumor tissue of NSCLC is closely related to TNM stage and metastasis of lymph node. VEGFR-3 detection can be seen as a criterion for evaluation.更多还原