【摘要】 为了观察中药石上柏对晚期鼻咽癌的放射增敏作用及急性放射反应,选择160例晚期鼻咽癌患者分为单放组(80例)和中药组(80例)进行临床随机对照实验。单放组患者仅接受单纯放疗;中药组从放疗第1天开始,每日用石上柏30g煎水50mL口服,至放疗结束。中药组患者鼻咽原发灶、颈淋巴结转移灶的CR率分别为37.50%(30/80)和56.25%(45/80),均高于单放组的22.50%(18/80)和40.00%(32/80),两组比较差异有统计学意义,χ2值分别为4.286和4.231,P值分别为0.038和0.040。中药组患者的急性放射反应较单放组轻,差异有统计学意义,P<0.05。初步研究结果提示,石上柏对晚期鼻咽癌有一定的放射增敏作用,并且能减轻急性放射反应。更多还原

【Abstract】 To observe the effect of radiosensitization of the Chinese herbal selaginella for terminal Nasopharyngeal Carcinoma (NPC). 160 patients with terminal NPC were divided into two groups. Radiotherapeutic methods were same for the two groups. 80 patients whom radiotherapy alone was given,and the other 80 patients whom radiotherapy was given in association with selaginella 30g to be taken dailly in whole course of radiotherapy. The CR rate of nasopharyngeal primary lesion and cervical lymph of the patients taking selaginella was 37.50%(30/80) and 56.25%(45/80) separately. The CR rate of nasopharyngeal primary lesion and cervical lymph of the patients with radiotherapy alone was 22.50%(18/80)and 40.00%(32/80)separately. There was statistical significance of difference. χ2 value was 4.286 and 4.231 separately. P value was 0.038 and 0.040 separately. Acute irradiation effects of the patients taking selaginella was significantly softer than the patients with radiotherapy alone with significant differences. P value <0.05. From the results of this study, we concluded that the Chinese herbal selaginella had effect of radiosensitization for terminal NPC and decreasing acute effects of radiotherapy.更多还原