【摘要】 目的:观察甘氨双唑钠(sodiumglyci-didazole,CMNa)在中晚期鼻咽癌放射治疗中的作用。方法:60例中晚期鼻咽癌患者随机分观察组(CMNa+放疗)和对照组(单纯放疗组)各30例。CMNa静脉滴入,每次0·75g,每周1、3和5用药,用药后1h内放疗。放疗采用常规外照射方案。结果:鼻咽原发灶CR率在观察组和对照组分别是93%和73%,两组差异有统计学意义,χ2=4·320,P=0·0377。颈淋巴结CR率两组分别是90%和63%,两组差异亦有统计学意义,χ2=5·963,P=0·0146。两组毒副反应如皮肤、黏膜、消化道反应及血白细胞下降等差异无统计学意义,P>0·05。结论:CMNa联合放射治疗可提高鼻咽癌的肿瘤局部控制率,而毒副反应不增加。更多还原

【Abstract】 OBJECTIVE:To observe the clinical effect of CMNa on the radiotherapy of middle and advanced nasopharyngeal carcinoma. METHODS: Sixty patients with middle and advanced NPC were randomly divided into observable group (CMNa+radio group, n=30) and control group (radio group, n=30).CMNa was used by venous injectiore, 0.75 g per once, 3 times per week. All patients underwent the same radiotherapy. RESULTS: The CR rates of NP in observable group and control group were 93% and 73% respectively. The CR rates of neck lymph node were 90% and 63%,respectively. There was no significant difference in toxicity between the two groups,P>0.05. CONCLUSIONS: CMNa combined with radiotherapy can raise the local control rate of NPC and the toxicity does not increase.更多还原