【摘要】 目的探讨急性脑梗死患者尿8-异前列腺素F2α排出量的变化,明确其体内氧化自由基产生情况。方法选取20例脑梗死患者作为试验组,根据发病时间分别测定发病24h内和发病第14d时尿8-异前列腺素F2α的浓度。并根据标准选取19例体检者作为对照组。结果(1)脑梗死患者发病24h内和发病第14d时尿8-异前列腺素F2α的浓度与正常对照组间差别有显著性意义(P<0.01);(2)脑梗死患者发病第14d时与发病24h内尿8-异前列腺素F2α浓度间差别有显著性意义(P<0.01)。结论急性脑梗死患者体内脂质过氧化有显著增加,常规治疗第14d时体内氧化应激反应仍在加重。更多还原

【Abstract】 Objective To investigate the excretion of urinary 8-isoprostanes F_ 2α in the patients with acute cerebral infarction.Methods 20 patients with cerebral infarction were chosen as assay group according to selection criterion,and 19 individuals were chosen as control group.Plasma and urinary samples of each patient were collected within 24 hours and 2 weeks after onset separately.The concentration of urinary 8-isoprostanes F_ 2α and creatinine were measured in each sample.Results (1)The concentration of urinary 8-isoprostanes F_ 2α within 24 hours and 2 weeks after onset in the assay group is significantly higher than those of the control group (P<0.01).(2)The concentration of urinary 8-isoprostanes F_ 2α of 2 weeks after onset is significantly higher than that within 24 hours after onset in the patients with acute cerebral infarction.Conclusion Urinary 8-isoprostanes F_ 2α increased in the patients with acute cerebral infarction,and there is a higher level of lipid peroxidation on the fourteenth day after onset.更多还原