【摘要】 目的探讨乌司他丁治疗严重多发伤的临床价值。方法将160例严重多发伤患者随机分为试验组(80例)和对照组(80例)。试验组患者在常规治疗的基础上,自入院当天开始连续7d静脉滴注乌司他丁(UTI),对照组患者只予常规治疗。对比两组患者治疗前后血清中炎症递质、肝肾功能变化以及临床疗效。结果治疗第7d时,两组患者肿瘤坏死因子(TNF-α)、白介素-1(IL-1)、白介素-6(IL-6)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、尿素氮(BUN)、肌酐(Cr)的均值间差别均有显著性意义(P<0.01);两组患者并发症的发生率、平均住ICU时间、平均住院时间和器官功能衰竭发生率间差别均有显著性意义(P<0.01)。结论乌司他丁能抑制多发伤患者的部分炎症递质的分泌和释放,并保护重要脏器功能,降低并发症,有良好的临床疗效。更多还原

【Abstract】 Objective To evaluate the clinical value of ulinastatin on treating multiple injuries.Methods 160 patients with severe multiple injuries were randomly divided into two groups.In the treatment group (n=80),on the base of routine treatment,ulinastatin was administered intravenously for seven days from hospitalization,while in the control group only routine treatment was given (n=80).Inflammatory factors in serum,the change of liver function and renal function were measured between the two groups before and after the treatment,the clinical effects were observed too.Results There was significant difference in the serum level of TNF-α,IL-1,IL-6,ALT,AST,BUN and Cr on the 7th day between the two groups(P<0.01),there were significant differences in the incidence of complications,time in ICU,hospitalization time,incidence of multi-organ failure between the two groups(P<0.01).Conclusion Ulinastatin can suppress the secretion and release of part inflammatory factors,protect the important viscera functions and reduce the incidence of complications,and it has favorable clinical effect.更多还原