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复发性尖锐湿疣血清肿瘤坏死因子和白介素-6水平检测

Detection of TNF-α and IL-6 in serum of patients with recurrent condyloma acuminatum

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【作者】 林爱华金纳朱可建程浩

【Author】 LIN Aihua,JIN Na,ZHU Kejian,CHENG Hao.Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China

【机构】 浙江大学医学院附属邵逸夫医院皮肤科浙江大学医学院附属邵逸夫医院皮肤科

【摘要】 目的检测尖锐湿疣患者血清中肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)的水平,探讨其在疾病发生中的作用。同时检测复发的尖锐湿疣患者血清TNF-α和IL-6的水平,以了解这两个细胞因子在疾病复发中的意义。方法采用ELISA法检测73例尖锐湿疣患者和30例健康人血清TNF-α和IL-6水平,并对该73例中29例复发的尖锐湿疣患者和44例未复发的患者进行以上细胞因子的检测。结果患者组血清TNF-α和IL-6水平均低于健康人对照组,差异有统计学意义(均P<0.01)。复发组患者的TNF-α和IL-6水平显著低于未复发组(均P<0.05)。结论尖锐湿疣患者血清TNF-α和IL-6水平的低下可能是导致疾病发生和复发的重要原因之一。

【Abstract】 Objective To detect cytokine levels of TNF-α and IL-6 in the serum of patients with condyloma acuminatum and investigate their role in disease recurrence.Methods ELISA was used to study TNF-α and IL-6 in the serum of 73 patients with condyloma acuminatum and 30 healthy volunteers.Of the 73 patients,44 were nonrecurrent cases and 29 were recurrent condyloma acuminatum cases.TNF-α and IL-6 in the serum of both recurrent and nonrecurrent patients were detected Results Compared with healthy controls,patients with condyloma acuminatum showed a decreased level of TNF-α and IL-6(<I>P</I><0.01).TNF-α and IL-6 were significantly lower in patients of recurrent group in comparison with nonrecurrent group(<I>P</I><0.05).Conclusion Low level of TNF-α and IL-6 in patients with condyloma acuminatum may be an important cause of disease development and recurrence.

【关键词】 尖锐湿疣肿瘤坏死因子-α白介素-6
【Key words】 condyloma acuminatumTNF-αIL-6
  • 【文献出处】 全科医学临床与教育 ,Clinical Education of General Practice , 编辑部邮箱 ,2006年06期
  • 【分类号】R752.53
  • 【下载频次】48
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