【摘要】 目的检测尖锐湿疣患者血清中肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)的水平,探讨其在疾病发生中的作用。同时检测复发的尖锐湿疣患者血清TNF-α和IL-6的水平,以了解这两个细胞因子在疾病复发中的意义。方法采用ELISA法检测73例尖锐湿疣患者和30例健康人血清TNF-α和IL-6水平,并对该73例中29例复发的尖锐湿疣患者和44例未复发的患者进行以上细胞因子的检测。结果患者组血清TNF-α和IL-6水平均低于健康人对照组,差异有统计学意义(均P<0.01)。复发组患者的TNF-α和IL-6水平显著低于未复发组(均P<0.05)。结论尖锐湿疣患者血清TNF-α和IL-6水平的低下可能是导致疾病发生和复发的重要原因之一。更多还原

【Abstract】 Objective To detect cytokine levels of TNF-α and IL-6 in the serum of patients with condyloma acuminatum and investigate their role in disease recurrence.Methods ELISA was used to study TNF-α and IL-6 in the serum of 73 patients with condyloma acuminatum and 30 healthy volunteers.Of the 73 patients,44 were nonrecurrent cases and 29 were recurrent condyloma acuminatum cases.TNF-α and IL-6 in the serum of both recurrent and nonrecurrent patients were detected Results Compared with healthy controls,patients with condyloma acuminatum showed a decreased level of TNF-α and IL-6(<I>P</I><0.01).TNF-α and IL-6 were significantly lower in patients of recurrent group in comparison with nonrecurrent group(<I>P</I><0.05).Conclusion Low level of TNF-α and IL-6 in patients with condyloma acuminatum may be an important cause of disease development and recurrence.更多还原