【摘要】 目的探讨肺纤维化患者血清层粘连蛋白(LN)、透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(CⅣ)检测的临床意义。方法采用放射免疫分析法检测肺纤维化组45例、肺炎组42例和正常对照组45例血清LN、HA、PCⅢ、CⅣ的含量并进行比较分析。结果肺纤维化组血清中LN(178．50±45．50)ng/ml、HA (162．50±50．00)ng/ml、PCⅢ(149．50±46．60)ng/ml、CⅣ(146．30±55．20)ng/ml水平显著高于肺炎组和正常对照组(P＜0．01),肺炎组与正常对照组比较,除CⅣ水平高于正常对照组(P＜0．05)外,其余差异无统计学意义(P＞0．05)。结论血清LN、HA、PCⅢ、CⅣ检测可作为肺纤维化诊断较好的无创性指标。更多还原

【Abstract】 Objective To study the clinical significance of serum Laminia (LN),Hyaluronate acid ( HA),Procollagen TypeⅢ(PCⅢ)and Collagen TypeⅣ(CⅣ)in patients with pulmonary fibrosis.Methods The levels of serum LN, HA,PCⅢand CⅣin 45 patients with pulmonary fibrosis,42 cases with pneumonia and 45 cases healthy people were detected by radioimmunoassay.Results The levels of serum LN,HA,PCⅢand CⅣin patients with pulmonary fibrosis were significantly increased than those in pneumonia group and healthy group (P＜0.01).Conclusions Co-detections of serum LN,HA ,PCⅢand CⅣwere effective and non-invasive indexes in the diagnosis of pulmonary fibrosis.更多还原