【摘要】 以4-甲砜基甲苯为起始原料,经硝化、氧化、酰化、缩合和转位等5步反应合成硝磺酮。中间体2-硝基-4-甲砜基甲苯和2-硝基-4-甲砜基苯甲酰氯不需从反应体系中分离出来,直接用于后续反应,总收率64%,产品纯度超过96%。田间药效试验结果表明,在用药量为97.5￣150ga.i./hm2时能有效防除玉米田鸭跖草、苘麻、蓼、铁苋菜、藜、反枝苋等双子叶杂草,对马唐、稗草、狗尾草等单子叶杂草也有一定的防除作用,对玉米安全。更多还原

【Abstract】 Mesotrione was synthesized via five-step reactions such as nitration, oxidation, acylation, condension and rearrangement from 4-methylsulfonyl toluene used as the starting reagent. The intermediates 2-nitro-4-methylsulfonyl toluene and 2-nitro-4-methylsulfonylbenzoyl chloride could be used directly without isolation from the system. The total yield was 64%, with a purity more than 96%. Field experiments indicated that mesotrione at dosage of 97.5-150 g a.i./ha had effective control of dicotyledoneae such as Commelina communis L., Abutilon theophrasti Medicus, Polygonaceae, Acalypha australis L., Chenopodium album L., Amaranthus retroflexus L. etc., and also had some effect on monocotyledoneae such as Digitaria sanguinalis(L.)Scop., Echinochloa crusgalli(L.)Beauv. and Se- taria viridis(L.)Beauv. Mesotrione was much safe to corn.更多还原