【摘要】 目的研究急性心肌梗死(AMI)患者发病不同阶段血浆神经肽Y(NPY)、神经降压素(NT)水平的变化,探讨其在AMI的发生发展中的意义。方法采用放射免疫方法(RIA)测定53例AMI患者发病后第1、2、3、7、14天血浆NPY、NT的浓度变化,并选择40例健康者作对照组。结果AMI患者发病后第1、2、3天血浆NPY[(268±34)pg/ml(、217±37)pg/ml(、196±48)pg/ml]、NT[(163±27)pg/ml(、125±23)pg/ml(、71±24)pg/ml]明显高于对照组[NPY(115±27)pg/ml,NT(66±13)pg/ml](P<0.01),合并有泵功能衰竭的患者血浆NPY、NT水平明显高于泵功能正常患者[NPY(326±28)pg/ml vs(215±34)pg/ml,NT(195±32)pg/ml vs(106±37)pg/ml](P<0.01)。结论NPY、NT与AMI的病理生理过程有关,可能在AMI发生发展中发挥作用。更多还原

【Abstract】 Objective To study the changes in plasma neuropeptide Y(NPY) neurotensin(NT) levels in patients with acute myocardial infarction(AMI),and to investigate the significance of theirs changes in AMI.Methods Fifty-three patients with AMI,forty normal controls were studied.Plasma NPY and NT were measured by radioimmuoaussay(RIA) in patients with AMI after admission,1day,2 day,3 day,7 day,14 day.Results The plasma NPY and NT levels in patients after AMI 1 day,2 day,3 day were[(268±34)pg/ml;(163±27)pg/ml],[(217±37)pg/ml;(125±23)pg/ml],[(196±48)pg/ml;(71±24)pg/ml];and they were singnifcantly higher than those in normal controls[NPY(115±27)pg/ml,NT(66±13)pg/ml].what’s more,the levels of plasma NPY and NT in patients with heart failure were significantly higher than the patients with normal cardiac function[NPY(326±28)pg/ml vs(215±34)pg/ml,NT(195±32)pg/ml vs(106±37)pg/ml](P<0.01).(Conclusion) NPY,NT are associated with the pathophysical progression and might play an role in the development of AMI.更多还原