【摘要】 目的探讨血清中细胞因子在慢性前列腺炎(CP)诊断、分型中的意义。方法用ELISA法检测146例临床诊断的慢性前列腺炎患者[其中慢性细菌性前列腺炎(CBP)组52例、慢性非细菌性前列腺炎(CAP)Ⅰ组66例、Ⅱ组28例]血清中的细胞因子,如IL-2、IL-4、IL-6、IL-8、TNF-α,同时,以20例健康男性作为正常对照,并对所取得的数据进行统计学分析。结果(1)IL-2、IL-4在CBP组、CAPⅠ组患者血清中均有不同程度的升高,与正常对照组比较差异显著(P<0．01或P<0．05),而CBP组与CAPⅠ组、CAPⅡ组与正常对照组间比较均无显著性差异(P>0．05);(2)IL-6、IL-8在CBP组、CAPⅠ组、CAPⅡ组、正常对照组间相互比较均有显著性差异(P<0．01或P<0．05);TNF-α在CBP组、CAPⅠ组、正常对照组间相互比较差异显著(P<0．01或P<0．05),CAPⅡ组与正常对照组间比较差异无显著性(P>0．05)。结论血清中IL-2、IL-4、IL-6、IL-8、TNF-α水平可能在CP的发生发展过程中起作用,对CP辅助性诊断有较大应用价值,其中IL-6、IL-8、INF-α对CP的诊断、分型有一定临床意义。更多还原

【Abstract】 Objective To investigate the significance of the determinating cytokines in serum for evaluation of chronic prostatitis(CP). Methods The levels of interleukin-2(IL-2), interleukin-4(IL-4), interleukin-6(IL-6), interleukin-8(IL-8), tumor necrosis factor-α(TNF-α) in serum were detected by ELISA in 146 patients with CP[CBP52cases, CAPⅠ66cases and CAPⅡ28cases], and 20 healthy males as control, and statistical analysis was performed. Results (1)The serum levels of IL-2,IL-4 in patients with CBP and CAPⅠwere significantly higher than those of control and difference was obvious between the patients with CBP or CAPⅠand Control (P<0.01 or P<0.05 ), there was no significant difference between CBP, CAPⅠ, CAPⅡand control (P>0.05). (2)The levels of IL-6, IL-8 were significantly different among CBP, CAPⅠ, CAPⅡand control (P<0.01 or P<0.05); the level of TNF-αwere significantly different among CBP , CAPⅠand control (P<0.01 or P<0.05), there was no significant difference between CAP II and control (P>0.05). Conclusion The levels of IL-2, IL-4, IL-6, IL-8,TNF-αin serum play a role in process of the occurrence and development of CP and there are applied values to help diagnosis of CP. As to diagnosis and typing of CP, IL-6,IL-8,TNF-αare especially meaningful.更多还原