【摘要】 目的:探讨急性冠脉综合征(ACS)患者血浆瘦素(leptin)水平的变化及其临床意义。方法:设急性心肌梗死组(AMI组)(n=30,男性)、不稳定性心绞痛组(UA组)(n=30,男性),分别抽取AMI组患者入院第1d、UA组患者心绞痛发作24h内及病情稳定后(2周无缺血事件发生)和对照组静脉血,通过酶联免疫法测定血浆leptin浓度。结果:AMI组患者入院第1d血浆leptin浓度(3.20±0.83ng/ml)较正常对照组(2.06±0.82ng/ml)显著升高,P<0.05,AMI组患者血浆leptin浓度与血浆C反应蛋白(CRP)浓度之间呈显著正相关关系(r=0.47,P<0.05);AMI组患者第1d与UA组患者心绞痛发作24h内血浆leptin水平有显著性差异,P<0.05。UA患者心绞痛发作24h内血浆leptin水平(2.67±0.79ng/ml)与病情稳定后的血浆leptin水平(2.19±0.91ng/m1)以及对照组比较,均有显著性差异,P<0.05,UA组患者病情稳定后的血浆leptin水平略高于对照组,无显著性差异,P>0.05。UA组患者心绞痛发作24h内的血浆leptin浓度与血浆CRP浓度呈显著正相关关系(r=0.76,P<0.05)。结论:男性ACS患者血浆leptin水平升高与组织炎症反应相关,leptin水平在男性ACS患者中的升高一定程度上可能代表了动脉粥样硬化斑块的易损性,是一个重要的冠心病危险因素和不稳定斑块的监测指标。更多还原

【Abstract】 Objective:To evaluate the level of Leptin in ACS and their relationship.Methods:Plasma leptin levels were measured in 30male-patients With unstable angina(UA)on first day and 14 days later,30 male—patients with AMI on day 1 after MI.and 30 normal subjects.Other subjects were also measured.Results:Leptin levels of 30 AMI patients on first day are significantly higher than that of the UA(p<0.05).We found that leptin correlated with CRR Leptin levels of UA were significantly higher than that of the controls(p<0.05).then drop to normal after careful therapy.We found that leptin correlated with CRP in UA.Conclusion:Plasma leptin levels have a significance correlation with CRP in AMI.Leptin may play an important role in the inflammation of ACS in males.Leptin may be an important risk factor for coronary heart disease and a indicator of unstable plaque.更多还原