【摘要】 目的:研究喉鳞状细胞癌的发生与HPV 16/18的相关性。方法:采用原位杂交法检测54例喉癌中HPV 16/18的表达。结果:54例喉癌组织中30例HPV 16/18阳性,喉癌组HPV 16/18的阳性表达为55.6%,癌旁不典型增生组为38.1%,二者比较有显著性差异(P<0.05);HPV 16/18在癌周正常组织、癌旁单纯增生及轻度不典型增生组织中无表达。随着不典型增生程度的增大,HPV 16/18阳性表达率增高,轻、中、重度增生分别为0%、7.1%和12.5%;HPV 16/18的表达与喉癌的分化程度及有无淋巴结转移无关(P>0.05)。结论:HPV 16/18与喉癌的发生有关,与喉癌的分化程度及有无淋巴结转移无关。更多还原

【Abstract】 Objective: To study the pathogenic relation between human papilloma virus and laryngeal squamous cell carcinomas.Methods: In situ hybridization method was used in 54 cases of laryngeal carcinoma.[WTHZ]Results: In 54 cases of laryngeal carcinoma,30 cases showed HPV16/18 expression. The frequency of HPV16/18 expression in laryngeal carcinoma and hyperplasia were 55.6% and 38.1% respectively($P$<0.05).There was no expression of HPV16/18 in normal laryngeal mucosa,simple hyperplasia and mild atypical hyperplasia,There was high expression of HPV16/18 with progressing of atypical hyperplasia.The frequency of HPV16/18 expression of mild atypical hyperplasia was 0%,medium atypical hyperplasia was 7.1% and serious atypical hyperplasia was 12.5%;and there was no relation with differentiation and lymph node metastasis($P$>0.05).Conclusion: The pathogenesis of laryngeal squamous cell carcinoma is closely related with HPV16/18 infection.There was no relation with differentiation and lymph node metastasis.更多还原