【摘要】 目的:了解氯氮平并小量碳酸锂治疗首发精神分裂症的临床疗效和安全性.方法:采用氯氮平平均剂量为(247±61)mg/d并碳酸锂0.75 g/d治疗首发精神分裂症45例,疗程8 w,治疗前后进行PANSS、BPRS评定.副反应主要根据临床观察、心电图及实验室检查.结果:合并治疗8 w后PANSS量表和BPRS量表的减分率有明显的下降,t检验有统计学意义(p<0.01),未见严重的不良反应.结论:氯氮平并小量碳酸锂治疗首发精神分裂症疗效显著,副反应少、安全性强,可能减轻白细胞下降的程度,或减少白细胞降低的发生率.更多还原

【Abstract】 Objective: To explore the efficacy and safety of clozapine combining with low-dose Lithium Carbonate in the treatment of first-onset schizophenia.Method: 45 patients with first-onset schizephrenia were treatment with clozapine(247±61mg/d) and Lithium Carbonate(0.75g/d).The efficacy was measured with PANSS and BPRS.The side-effect were assessed with electrocardiogram,laboratory result and clinical observation.Result: After eight weeks treatment,there were significant decrease of BPRS and PANSS total scores,and no serious side-effect.Conclusion: It is suggested that clozapine combining with low-dose Lithium Carbonate have marked effectiveness in the treatment of first-onset schizephrenia,and the side-effect is lower,it also can reduce the incidence of leukopenia.更多还原