【摘要】 采用DM F法合成了4-二甲氨基吡啶,并对该合成工艺进行了优化.由吡啶与氯化亚砜合成中间体双吡啶盐酸盐的收率从文献报道的57%提高到65%;由中间体与DM F合成目标化合物的收率从文献报道的53%提高到73%.所用合成方法简化了操作步骤,降低了合成成本,减少了三废排放.更多还原

【Abstract】 4-Dimethylaminopyridine was synthesized using the DMF method and optimum conditions.The intermediate 1-(4-pyridinio)pyridinium dichloride was synthesized by pyridine and sulphurous oxychloride,The yield was improved from 57%(literatures) to 65%.Specially,the yield of target compound was improved from 53%(literatures) to 73%.We provided a simple way to synthesize 4-Dimethylaminopyridine.更多还原