【摘要】 目的:探讨联合检测嗜铬粒蛋白A(CgA)和前列腺特异性抗原(PSA)在前列腺癌(PCa)诊断中的意义。方法:采用ELISA法测定50例健康志愿者(正常对照组),55例PCa患者(PCa组)及25例良性前列腺增生患者(BPH组)血清中的CgA及PSA。结果:PCa组与正常对照组及BPH组比较差别有显著性意义(P<0.05)。血清CgA水平随癌分期的升高而升高。CgA和PSA对PCa的诊断的平行、系列试验的灵敏度和特异度明显高于单独一种检验结果。结论:联合检测CgA和PSA对提高PCa诊断的准确率具有重要的临床意义,对PCa的分期及预后评价亦有一定的意义。更多还原

【Abstract】 Objective: To evaluate the significance of the combined assay of chromogranin A(CgA) and prostate specific antigen(PSA) in the diagnosis of prostate cancer.Methods: Serum CgA and PSA were detected by ELISA technique in 55 cases of prostate cancer(PCa),25 cases of benign prostate hyperplasia(BPH),and 50 cases of normal subjects(control). Results: The serum CgA level in the PCa group was significantly higher than those in the control and BPH groups(P<(0.05)),and increased with clinical stages.The parallel and serial tests associated with serum PSA and CgA raised the rate of detection of prostate cancer.Conclusion: The combined assay of serum PSA and CgA is of significant clinical value in raising the rate of diagnosis of prostate cancer,as well as in staging and prognosing the disease更多还原