【摘要】 类固醇激素合成急性调节蛋白(StAR)是类固醇激素合成过程中的重要调节因素。它具有高度的组织特异性,位于相关细胞的线粒体膜上,参与类固醇激素的前体———胆固醇由线粒体外膜向线粒体内膜的转运,此过程是类固醇激素合成的限速步骤。最近的研究表明,StAR的转录及翻译水平不仅受cAMP-PKA信号通路的影响,而且还受多种促性腺激素、细胞因子的调控,从而影响着机体类固醇激素的合成。更多还原

【Abstract】 The steroidogenic acute regulatory(StAR) protein is an essential component in the regulation of steroid biosynthesis in adrenal and gonadal cells.The StAR protein has a high tissue specificity,located on the mitochondrial membranes of some relative cells.It regulates the transfer of cholesterin from extracellular into intracellular and plays a dominant role in steroidogenic synthesis.Recent studies have also shown that the transcription and expression of StAR are modulated not only through the cAMP-PKA dependent pathway,but also by multiple hormones and cytokines,which contributes to the regulation of cholesterin synthesis.更多还原