【摘要】 将供体精原细胞移植入异基因受体生精小管中,可看到供体精原细胞分化形成供体形态特征的精子。伴随着冷冻保存、体外培养和干细胞富集技术的发展,精原细胞异基因移植必将在基础科学、临床医学、动物繁殖等领域有非常重要的应用前景。另外,这些技术也可用于接受大剂量放疗或化疗的肿瘤患者的性腺保护和生育力保存。本文综述精原细胞异基因移植研究进展,并对该技术在今后临床应用中所存在的问题进行讨论。更多还原

【Abstract】 Results from the transplantation of donor spermatogonia into xenogeneic recipient seminiferous tubules indicate that donor germ cells are capable of differentiating to form spermatozoa with morphological character of the donor species. With the advances in freezing, culturing in vitro and enriching germ cell populations, germ cell transplantation procedures have applications of paramount values in medicine, basic science and animal reproduction. Additionally, these techniques can serve as an alternative approach for gonadal protection and fertility preservation especially in patients accepting large dose of chemotherapy or radiotherapy. In this article we reviewed the recent advances in xenogeneic transplantation of spermatogonial stem cell and also analyzed the potential problems existing in its clinical application.更多还原