【摘要】 目的:探讨环氧化酶2(COX-2)mRNA在前列腺癌(PCa)组织中的表达及其意义。方法:采用RT-PCR方法检测32例PCa组织中COX-2 mRNA的表达并测定COX-2/GAPDH的比值,7例正常前列腺组织作为对照。结果:7例正常前列腺组织无COX-2 mRNA表达。COX-2/GAPDH与PCa G leason评分、分期呈正相关(P均<0.05)。结论:COX-2在PCa的发生发展中起重要的正性调节因子的作用。COX-2与PCa的恶性程度和进展有关,可作为判断PCa预后的指标。更多还原

【Abstract】 Objective: To investigate the relationship between cyclooxygenase-2(COX-2) mRNA expression and the biological behaviors of prostate carcinoma(PCa).Methods: The expression of COX-2 mRNA was detected by RT-PCR method in 32 samples of PCa and the COX-2/GAPDH value was determined.Seven normal prostate tissues were served as control. Results: The expression of COX-2 mRNA in normal tissue of 7 control cases was all negative.There was statistical correlation between the COX-2/GAPDH and the Gleason scores of PCa.There also showed statistical correlation between the COX-2/GAPDH and the stages of PCa.Conclusion: COX-2 mRNA play an important role in occurrence and progression of the PCa.COX-2 is a tumor marker which may be the possible prognostic factor of PCa. Natl J Androl,2006,12(2):159-161更多还原