【摘要】 目的:探讨血清和前列腺按摩液(EPS)中细胞因子与慢性非细菌性前列腺炎(CAP)的关系。方法:用ELISA法对86例CAP患者(其中CAPⅠ组60例,WBC≥10个/HP;CAPⅡ组26例,WBC<10个/HP)血清和EPS进行白细胞介素2(IL-2)、IL-4、IL-8、肿瘤坏死因子α(TNF-α)检测,同时,以20例健康男性作对照,并对所获得的数据进行统计学分析。结果:CAPⅠ组血清和EPS中的IL-2、IL-8、TNF-α,以及血清IL-4均有不同程度的升高,与对照组相比差异有显著性(P<0.05或P<0.01),EPS中的IL-4在CAPⅠ组、CAPⅡ组、对照组间比较差异无显著性(P>0.05),CAPⅡ组血清和EPS中的IL-2、IL-4、TNF-α与对照组相比无显著性差异(P>0.05);EPS中WBC数与IL-8水平存在相关性(r=0.62,P<0.05)。结论:IL-2、IL-8、TNF-α水平可能在CAP发生发展过程中起作用,对CAP的辅助性诊断和分型有一定应用价值。更多还原

【Abstract】 Objective: To investigate the relationship between four cytokines in serum and prostatic fluid and chronic abacterial prostatitis(CAP).Methods: The levels of interleukin-2(IL-2),IL-4,IL-8,tumor necrosis factor-α(TNF-α) were detected in 86 patients with CAP[CAPⅠ(n=60),WBC≥10/HP;CAPⅡ(n=26,WBC<10/HP)],and 20 healthy males as control by ELISA.Results: IL-2,IL-8 and TNF-α in serum and prostatic fluid,and IL-4 in serum in patients with CAPⅠ were markedly higher than those in the control,respectively(P<(0.05) or P<(0.01)).No significant difference was observed in IL-4 level in prostatic fluid among CAPⅠ,CAPⅡ and control groups respectively(P>(0.05)),and in IL-2,IL-4,TNF-α in serum and prostatic fluid between CAPⅡ group and the control(P>(0.05)).IL-8 was correlated with WBC number in prostatic fluid(r=(0.62),P<(0.05)).Conclusion: IL-2,IL-8,TNF-α may play roles in the process of pathogenesis of CAP,and they have applicable value in the diagnosis and typing of CAP.更多还原