【摘要】 目的:探讨颈动脉粥样硬化(CAS)的危险因素及与相关炎症因子产生的关系。方法:入选的83例对象均行彩色多普勒检测颈动脉内中膜厚度(IMT)及观察颈动脉有无斑块,根据结果分成A组即CAS组(颈动脉IMT≥1.0mm和/或颈动脉斑块)及B组(颈动脉IMT<1.0mm及无颈动脉斑块),分析两组各危险因素和炎症因子产生之间的差异。结果:A组中血脂代谢紊乱、收缩压(SBP)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C),血尿酸(UA),脂蛋白a(Lp(a)),超敏C反应蛋白(Hs-CRP),白介素6(IL-6)及纤维蛋白原(FIB)较B组差异明显(P<0.05)。Logistic多元回归分析发现,男性、LDL-C、IL-6是CAS的独立危险因素。结论:在CAS的发生发展中除了传统的危险因素外,炎症因子也起了非常重要的作用。更多还原

【Abstract】 Objective:To analyze the risk factors of carotid atherosclerosis(CAS).Methods:Totally 83 patients were examined by B-mode ultrasound to measure intima-media thickness(IMT)of the common carotid artery and plaque formation.The patients were divided into group A(carotid IMT ≥ 1.0 mm and/or the presence of carotid plaque)and group B(carotid IMT < 1.0 mm and the absence of carotid plaque).The differences of the risk factors between two groups were analyzed.Results:The levels of systolic blood pressure(SBP),total cholesterol(TC),low dense lipoprotein cholesterol(LDL-C),uric acid(UA),lipoprotein a[Lp(a)],high sensitive C-reactive protein(Hs-CRP),Interleukin-6(IL-6)and fibrinogen(FIB)in group A were significantly higher than those in group B(P < 0.05).The result of logistic regression analysis indicated that male,LDL-C and IL-6 were the independent risk factors.Conclusion:The traditional risk factors and the inflammatory markers are strongly and closely related to the occurrence and development of CAS.更多还原