【摘要】 目的:研究大鼠牙髓及牙周组织中神经肽SP免疫阳性神经纤维的分布情况。方法:采用冰冻切片和间接免疫荧光方法观察大鼠牙髓、牙周膜以及牙龈内SP免疫阳性神经纤维的表达。结果:SP免疫阳性神经纤维在大鼠牙龈和牙髓组织中分布较多,而在牙周组织中分布较少,并且主要分布在根中和根尖1/3的部位。无论在牙髓或牙周,SP免疫阳性神经纤维多沿血管分布。结论:牙髓及牙周组织中均有SP免疫阳性神经纤维的分布,并可能通过调节牙髓和牙周血管功能等途径,在其损伤和炎症反应中发挥作用。更多还原

【Abstract】 Objective To investigate the localization of substance P-Like immunoreactivity nerve fibers in rat dental pulp and periodontal tissues. Method substance P-like immunoreactivity was demonstrated by indirect immunoflurescence on frozen sections.Results Some Substance P-containing fibers were observed in the pulp horn and root pulp in general located around blood vessels;In the periodontal ligament, SP fibers were localized along the blood vessels in the middle and apical regions;Many SP-containing fibers were associated with the blood vessels in the lamina propria of gingiva. Conclusion It suggested that SP may be involved in the regulatition of pulpal and periontal blood flow and in neurogenic inflammation.更多还原